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Titel:

Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Yadav, M; Zhang, J; Fischer, H; Huang, W; Lutay, N; Cirl, C; Lum, J; Miethke, T; Svanborg, C
Abstract:
Toll-like receptor signaling requires functional Toll/interleukin-1 (IL-1) receptor (TIR) domains to activate innate immunity. By producing TIR homologous proteins, microbes inhibit host response induction and improve their own survival. The TIR homologous protein TcpC was recently identified as a virulence factor in uropathogenic Escherichia coli (E. coli), suppressing innate immunity by binding to MyD88. This study examined how the host MyD88 genotype modifies the in vivo effects of TcpC and w...     »
Zeitschriftentitel:
PLoS Pathog
Jahr:
2010
Band / Volume:
6
Heft / Issue:
9
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.ppat.1001120
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20886104
Print-ISSN:
1553-7366
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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