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Title:

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Rosemann, M; Ivashkevich, A; Favor, J; Dalke, C; Hölter, SM; Becker, L; Racz, I; Bolle, I; Klempt, M; Rathkolb, B; Kalaydjiev, S; Adler, T; Aguilar, A; Hans, W; Horsch, M; Rozman, J; Calzada-Wack, J; Kunder, S; Naton, B; Gailus-Durner, V; Fuchs, H; Schulz, H; Beckers, J; Busch, DH; Burbach, JP; Smidt, MP; Quintanilla-Martinez, L; Esposito, I; Klopstock, T; Klingenspor, M; Ollert, M; Wolf, E; Wurst, W; Zimmer, A; de Angelis, MH; Atkinson, M; Heinzmann, U; Graw, J
Abstract:
A new spontaneous mouse mutant was characterized by closed eyelids at weaning and without apparent eyes (provisional gene name, eyeless; provisional gene symbol, eyl). The mutation follows a recessive pattern of inheritance and was mapped to the region of chromosome 19 containing Pitx3. Genetic complementation tests using Pitx3 ( ak/+ ) mice confirmed eyl as a new allele of Pitx3 (Pitx3 ( eyl )). Sequencing of the Pitx3 gene in eyl mutants identified an inserted G after cDNA position 416 (416in...     »
Journal title abbreviation:
Mamm Genome
Year:
2010
Journal volume:
21
Journal issue:
1-2
Pages contribution:
13-27
Language:
eng
Fulltext / DOI:
doi:10.1007/s00335-009-9235-0
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20033184
Print-ISSN:
0938-8990
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Dermatologie und Allergologie
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