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Title:

Chlamydophila pneumoniae downregulates MHC-class II expression by two cell type-specific mechanisms.

Document type:
Journal Article
Author(s):
Peschel, G; Kernschmidt, L; Cirl, C; Wantia, N; Ertl, T; Durr, S; Wagner, H; Miethke, T; Rodriguez, N
Abstract:
Chlamydophila pneumoniae was shown to prevent IFN gamma-inducible upregulation of MHC-class II molecules by secreting chlamydial protease-like activity factor (CPAF) into the cytosol of those host cells which support the complete bacterial replication cycle. CPAF acts by degrading upstream stimulatory factor 1 (USF-1). However, in cells like bone marrow-derived macrophages (BMM), which restrict chlamydial replication, we show that CPAF expression is barely detectable and the expression of USF-1...     »
Journal title abbreviation:
Mol Microbiol
Year:
2010
Journal volume:
76
Journal issue:
3
Pages contribution:
648-61
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1365-2958.2010.07114.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20233301
Print-ISSN:
0950-382X
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX