User: Guest  Login
Less Searchfields
Simple search
Title:

Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Yadav, M; Zhang, J; Fischer, H; Huang, W; Lutay, N; Cirl, C; Lum, J; Miethke, T; Svanborg, C
Abstract:
Toll-like receptor signaling requires functional Toll/interleukin-1 (IL-1) receptor (TIR) domains to activate innate immunity. By producing TIR homologous proteins, microbes inhibit host response induction and improve their own survival. The TIR homologous protein TcpC was recently identified as a virulence factor in uropathogenic Escherichia coli (E. coli), suppressing innate immunity by binding to MyD88. This study examined how the host MyD88 genotype modifies the in vivo effects of TcpC and w...     »
Journal title abbreviation:
PLoS Pathog
Year:
2010
Journal volume:
6
Journal issue:
9
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.ppat.1001120
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20886104
Print-ISSN:
1553-7366
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX