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Title:

Hemozoin: malaria's "built-in" adjuvant and TLR9 agonist.

Document type:
Comment; Journal Article
Author(s):
Wagner, H
Abstract:
The "built-in" adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a "built-in" adjuvant.
Journal title abbreviation:
Cell Host Microbe
Year:
2010
Journal volume:
7
Journal issue:
1
Pages contribution:
5-6
Language:
eng
Fulltext / DOI:
doi:10.1016/j.chom.2010.01.002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20114022
Print-ISSN:
1931-3128
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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