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Title:

Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Aguilar-Pimentel, JA; Alessandrini, F; Huster, KM; Jakob, T; Schulz, H; Behrendt, H; Ring, J; de Angelis, MH; Busch, DH; Mempel, M; Ollert, M
Abstract:
RATIONALE: Studies in humans and rodents have indicated a causative role for CD8(+) T cells in IgE-mediated allergic inflammation, but their function is still controversial. OBJECTIVES: To analyze the role of allergen-specific CD8(+) T cells during the development of allergic airway inflammation in two parallel but diverging outcome models. METHODS: We used H2-Kb SIINFEKL (OVA(257-264)) multimers to analyze induction, natural distribution, and phenotype of allergen-specific CD8(+) T cells in a m...     »
Journal title abbreviation:
Am J Respir Crit Care Med
Year:
2010
Journal volume:
181
Journal issue:
1
Pages contribution:
7-16
Language:
eng
Fulltext / DOI:
doi:10.1164/rccm.200902-0190OC
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19815810
Print-ISSN:
1073-449X
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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