Hemozoin: malaria's "built-in" adjuvant and TLR9 agonist.

Titel:: Hemozoin: malaria's "built-in" adjuvant and TLR9 agonist.
Dokumenttyp:: Comment; Journal Article
Autor(en):: Wagner, H
Abstract:: The "built-in" adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a "built-in" adjuvant.
Zeitschriftentitel:: Cell Host Microbe
Jahr:: 2010
Band / Volume:: 7
Heft / Issue:: 1
Seitenangaben Beitrag:: 5-6
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.chom.2010.01.002
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/20114022
Print-ISSN:: 1931-3128
TUM Einrichtung:: Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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