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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Meyerhuber, P; Conrad, H; Stärck, L; Leisegang, M; Busch, DH; Uckert, W; Bernhard, H
Titel:
Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes.
Abstract:
Human epidermal growth factor receptor 2 (HER2) has been successfully targeted as a breast cancer-associated antigen by various strategies. HER2 is also overexpressed in other solid tumors such as stomach cancer, as well as in hematological malignancies such as acute lymphoblastic leukemia. HER2-targeted therapies are currently under clinical investigation for a panel of malignancies. In this study, we isolated the T cell receptor (TCR) genes of a HER2-reactive allo-human leukocyte antigen-A2-re...     »
Zeitschriftentitel:
J Mol Med
Jahr:
2010
Band / Volume:
88
Heft / Issue:
11
Seitenangaben Beitrag:
1113-21
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00109-010-0660-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20700725
Print-ISSN:
0946-2716
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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