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Titel:

Chlamydophila pneumoniae downregulates MHC-class II expression by two cell type-specific mechanisms.

Dokumenttyp:
Journal Article
Autor(en):
Peschel, G; Kernschmidt, L; Cirl, C; Wantia, N; Ertl, T; Durr, S; Wagner, H; Miethke, T; Rodriguez, N
Abstract:
Chlamydophila pneumoniae was shown to prevent IFN gamma-inducible upregulation of MHC-class II molecules by secreting chlamydial protease-like activity factor (CPAF) into the cytosol of those host cells which support the complete bacterial replication cycle. CPAF acts by degrading upstream stimulatory factor 1 (USF-1). However, in cells like bone marrow-derived macrophages (BMM), which restrict chlamydial replication, we show that CPAF expression is barely detectable and the expression of USF-1...     »
Zeitschriftentitel:
Mol Microbiol
Jahr:
2010
Band / Volume:
76
Heft / Issue:
3
Seitenangaben Beitrag:
648-61
Sprache:
eng
Volltext / DOI:
doi:10.1111/j.1365-2958.2010.07114.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20233301
Print-ISSN:
0950-382X
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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