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Title:

B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Weber, MS; Prod'homme, T; Patarroyo, JC; Molnarfi, N; Karnezis, T; Lehmann-Horn, K; Danilenko, DM; Eastham-Anderson, J; Slavin, AJ; Linington, C; Bernard, CC; Martin, F; Zamvil, SS
Abstract:
Clinical studies indicate that anti-CD20 B-cell depletion may be an effective multiple sclerosis (MS) therapy. We investigated mechanisms of anti-CD20-mediated immune modulation using 2 paradigms of experimental autoimmune encephalomyelitis (EAE).Murine EAE was induced by recombinant myelin oligodendrocyte glycoprotein (rMOG), a model in which B cells are considered to contribute pathogenically, or MOG peptide (p)35-55, which does not require B cells.In EAE induced by rMOG, B cells became activa...     »
Journal title abbreviation:
Ann Neurol
Year:
2010
Journal volume:
68
Journal issue:
3
Pages contribution:
369-83
Language:
eng
Fulltext / DOI:
doi:10.1002/ana.22081
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20641064
Print-ISSN:
0364-5134
TUM Institution:
Neurologische Klinik und Poliklinik
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