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Titel:

Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Mahachie John, JM; Baurecht, H; Rodriguez, E; Naumann, A; Wagenpfeil, S; Klopp, N; Mempel, M; Novak, N; Bieber, T; Wichmann, HE; Ring, J; Illig, T; Cattaert, T; Van Steen, K; Weidinger, S
Abstract:
High levels of total and allergen-specific IgE levels are a key feature in allergic diseases. The high-affinity receptor for IgE, which is composed of one alpha (FCER1A), one beta (FCER1B), and two gamma (FCER1G) subunits, represents the central receptor of IgE-induced reactions. In a genome-wide association scan, we recently identified associations between functional FCER1A variants and total serum IgE levels. Previous studies had reported linkage and association of FCER1B variants with IgE and...     »
Zeitschriftentitel:
Allergy
Jahr:
2010
Band / Volume:
65
Heft / Issue:
7
Seitenangaben Beitrag:
875-82
Sprache:
eng
Volltext / DOI:
doi:10.1111/j.1398-9995.2009.02297.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20028371
Print-ISSN:
0105-4538
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie
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