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- Titel:
Expression and significance of FXYD-3 protein in gastric adenocarcinoma.
- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Zhu, ZL; Zhao, ZR; Zhang, Y; Yang, YH; Wang, ZM; Cui, DS; Wang, MW; Kleeff, J; Kayed, H; Yan, BY; Sun, XF
- Abstract:
- FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated in certain types of cancers (such as breast, prostate and pancreatic cancer), but down-regulated in other types of cancers (such as colon and kidney cancer). No study has been performed in gastric cancer; therefore, the aim of this project was to investigate FXYD-3 expression and its clinicopathological significance in gastric adenocarcinoma.FXYD-3 protein was examined by immunohistochemistry in normal gastric mucous (n= 29) and gastric adenocarcinoma (n=51), obtained from surgical resection of gastric cancer patients.FXYD-3 protein was present in the cytoplasm of normal gastric epithelial cells or gastric cancer cells. The rate of FXYD-3 strong expression was significantly higher in cancer (51% of 51) than in normal mucosa (10% of 29, X
; {2} =13.210, p < 0.0001). FXYD-3 expressed strongly in ulcerative/infiltrating types of cancers compared to polypoid/fungating ones (X; {2} =5.765, p=0.016). However, FXYD-3 expression was not correlated with patient's gender, age, tumor size, lymph node status and histological grade (p > 0.05). Conclosion: Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma. - Zeitschriftentitel:
- Dis Markers
- Jahr:
- 2010
- Band / Volume:
- 28
- Heft / Issue:
- 2
- Seitenangaben Beitrag:
- 63-9
- Sprache:
- eng
- Volltext / DOI:
- doi:10.3233/DMA-2010-0669
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/20364041
- Print-ISSN:
- 0278-0240
- TUM Einrichtung:
- Chirurgische Klinik und Poliklinik
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