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Document type:
journal article 
Author(s):
Mócsai, A; Ruland, J; Tybulewicz, VL 
Title:
The SYK tyrosine kinase: a crucial player in diverse biological functions. 
Abstract:
Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophi...    »
 
Journal title abbreviation:
Nat Rev Immunol 
Year:
2010 
Journal volume:
10 
Journal issue:
Pages contribution:
387-402 
Language:
eng 
Print-ISSN:
1474-1733 
TUM Institution:
III. Medizinische Klinik und Poliklinik