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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review 
Author(s):
Poeck, H; Ruland, J 
Title:
SYK kinase signaling and the NLRP3 inflammasome in antifungal immunity. 
Abstract:
Host protection against fungi depends on intact innate and adaptive immune responses. Consistently, fungal infections can cause systemic life-threatening diseases in immunocomprimised individuals, suffering e.g. from cancer or AIDS. Recent work has uncovered essential roles for the spleen tyrosine kinase (SYK) and the cytosolic NLRP3 inflammasome for Interleukin-1beta (IL-1beta) production in innate antifungal immunity. Upon fungal infection, SYK is activated by several C-type lectin pattern rec...    »
 
Journal title abbreviation:
J Mol Med 
Year:
2010 
Journal volume:
88 
Journal issue:
Pages contribution:
745-52 
Language:
eng 
Print-ISSN:
0946-2716 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center