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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Pechloff, K; Holch, J; Ferch, U; Schweneker, M; Brunner, K; Kremer, M; Sparwasser, T; Quintanilla-Martinez, L; Zimber-Strobl, U; Streubel, B; Gewies, A; Peschel, C; Ruland, J 
Title:
The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. 
Abstract:
Peripheral T cell lymphomas (PTCLs) are highly aggressive malignancies with poor prognosis. Their molecular pathogenesis is not well understood and small animal models for the disease are lacking. Recently, the chromosomal translocation t(5; 9)(q33; q22) generating the interleukin-2 (IL-2)-inducible T cell kinase (ITK)-spleen tyrosine kinase (SYK) fusion tyrosine kinase was identified as a recurrent event in PTCL. We show that ITK-SYK associates constitutively with lipid rafts in T cells and tri...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2010 
Journal volume:
207 
Journal issue:
Pages contribution:
1031-44 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1007 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center