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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
Author(s):
Dorhoi, A; Desel, C; Yeremeev, V; Pradl, L; Brinkmann, V; Mollenkopf, HJ; Hanke, K; Gross, O; Ruland, J; Kaufmann, SH 
Title:
The adaptor molecule CARD9 is essential for tuberculosis control. 
Abstract:
The cross talk between host and pathogen starts with recognition of bacterial signatures through pattern recognition receptors (PRRs), which mobilize downstream signaling cascades. We investigated the role of the cytosolic adaptor caspase recruitment domain family, member 9 (CARD9) in tuberculosis. This adaptor was critical for full activation of innate immunity by converging signals downstream of multiple PRRs. Card9(-/-) mice succumbed early after aerosol infection, with higher mycobacterial b...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2010 
Journal volume:
207 
Journal issue:
Pages contribution:
777-92 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1007 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Roman Herzog Comprehensive Cancer Center