Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET.

Titel:: Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET.
Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't
Autor(en):: Höfling, SB; Maschauer, S; Hübner, H; Gmeiner, P; Wester, HJ; Prante, O; Heinrich, MR
Abstract:: Radical (18)F-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been successfully applied to the radiochemical synthesis of the dopamine D(3)-selective ligand SH 317 ([(18)F]8). SH 317 has been evaluated as a new PET ligand candidate by in vivo experiments.
Zeitschriftentitel:: Bioorg Med Chem Lett
Jahr:: 2010
Band / Volume:: 20
Heft / Issue:: 23
Seitenangaben Beitrag:: 6933-7
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.bmcl.2010.09.142
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/21030255
Print-ISSN:: 0960-894X
TUM Einrichtung:: Klinik und Poliklinik für Nuklearmedizin
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