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Title:

NMD: RNA biology meets human genetic medicine.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Bhuvanagiri, M; Schlitter, AM; Hentze, MW; Kulozik, AE
Abstract:
NMD (nonsense-mediated mRNA decay) belongs to the best-studied mRNA surveillance systems of the cell, limiting the synthesis of truncated and potentially harmful proteins on the one hand and playing an initially unexpected role in the regulation of global gene expression on the other hand. In the present review, we briefly discuss the factors involved in NMD, the different models proposed for the recognition of PTCs (premature termination codons), the diverse physiological roles of NMD, the invo...     »
Journal title abbreviation:
Biochem J
Year:
2010
Journal volume:
430
Journal issue:
3
Pages contribution:
365-77
Language:
eng
Fulltext / DOI:
doi:10.1042/BJ20100699
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20795950
Print-ISSN:
0264-6021
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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