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Document type:
Zeitschriftenaufsatz
Author(s):
Allihn, Patrick W. A.; Hackl, Mathias W.; Ludwig, Christina; Hacker, Stephan M.; Sieber, Stephan A.
Title:
A tailored phosphoaspartate probe unravels CprR as a response regulator in Pseudomonas aeruginosa interkingdom signaling
Abstract:
Pseudomonas aeruginosa is a difficult-to-treat Gram-negative bacterial pathogen causing life-threatening infections. Adaptive resistance (AR) to cationic peptide antibiotics such as polymyxin B impairs the therapeutic success. This self-protection is mediated by two component systems (TCSs) consisting of a membrane-bound histidine kinase and an intracellular response regulator (RR). As phosphorylation of the key RR aspartate residue is transient during signaling and hydrolytically unstable, the...     »
Keywords:
BayBioMS;
Journal title:
Chemical Science
Year:
2021
Journal volume:
12
Journal issue:
13
Pages contribution:
4763-4770
Fulltext / DOI:
doi:10.1039/d0sc06226j
Publisher:
Royal Society of Chemistry (RSC)
E-ISSN:
2041-65202041-6539
Date of publication:
01.01.2021
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