Login
- Title:
Validation of an established prognostic score after re-irradiation of recurrent glioma.
- Document type:
- Journal Article; Validation Studies; Article
- Author(s):
- Kessel, Kerstin A; Hesse, Josefine; Straube, Christoph; Zimmer, Claus; Schmidt-Graf, Friederike; Schlegel, Jürgen; Meyer, Bernhard; Combs, Stephanie E
- Abstract:
- Re-irradiation (Re-RT) is offered widely in clinical routine, and has been established as a key element in the treatment of recurrent gliomas. At our center, generally re-resection is performed widely by an experienced neurosurgical team. Thus, Re-RT mostly offered to patients with macroscopic residuals or irresectable lesions, is applied later compared to other centers. Therefore, we sought to validate the Combs Prognostic Score developed in 2012 using our independent patient cohort.We included 199 patients treated from 2002 until April 2016 for recurrent glioma at the Department of Radiation Oncology at the Klinikum Rechts der Isar, Munich. Different concepts of Re-RT were applied.Median follow-up after Re-RT was 2.5 months. Median overall survival (OS) after Re-RT was 7.9 months for WHO IV gliomas, 11.3 months for WHO III gliomas, and 13.6 months for low-grade gliomas (WHO I/II). Univariate analyses confirmed the prognostic factors primary histology (p = 0.001), age (p = 0.002), and time between primary radiotherapy and Re-RT (p < 0.001). We also tested Karnofsky Performance Score (KPS), gender, and neurological symptoms before Re-RT as well as planning target volume and found only KPS also significant at p < 0.001. Comparing the prognostic score groups, the outcome was highly statistically significant at p < 0.001.In our analysis, we validated the Combs Prognostic Score. Validation in this independent large patient cohort confirms the significance of the score for glioma recurrences. Thus, the role of the Combs Prognostic Score might be an essential component of future clinical decision making and patient stratification.
- Journal title abbreviation:
- Acta Oncol
- Year:
- 2017
- Journal volume:
- 56
- Journal issue:
- 3
- Pages contribution:
- 422-426
- Language:
- eng
- Fulltext / DOI:
- doi:10.1080/0284186X.2016.1276621
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/28075197
- Print-ISSN:
- 0284-186X
- TUM Institution:
- Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Neurochirurgische Klinik und Poliklinik; Neurologische Klinik und Poliklinik
BibTeX
Occurrences:
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineKlinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)2017
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineKlinik und Poliklinik für Neurochirurgie (Prof. Meyer)2017
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsPreclinical MedicineInstitut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)2017
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineKlinik und Poliklinik für Neurologie (Prof. Hemmer)2017
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineInstitut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Abteilung für Diagnostische und Interventionelle Neuroradiologie (Prof. Zimmer)Professur für Neuroradiologie (Prof. Zimmer)2017