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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Trégouët, DA; König, IR; Erdmann, J; Munteanu, A; Braund, PS; Hall, AS; Grosshennig, A; Linsel-Nitschke, P; Perret, C; DeSuremain, M; Meitinger, T; Wright, BJ; Preuss, M; Balmforth, AJ; Ball, SG; Meisinger, C; Germain, C; Evans, A; Arveiler, D; Luc, G; Ruidavets, JB; Morrison, C; van der Harst, P; Schreiber, S; Neureuther, K; Schafer, A; Bugert, P; El Mokhtari, NE; Schrezenmeir, J; Stark, K; Rubin, D; Wichmann, HE; Hengstenberg, C; Ouwehand, W; Ziegler, A; Tiret, L; Thompson, JR; Cambien, F; Sch...     »
Titel:
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
Abstract:
We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.
Zeitschriftentitel:
Nat Genet
Jahr:
2009
Band / Volume:
41
Heft / Issue:
3
Seitenangaben Beitrag:
283-5
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.314
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19198611
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Humangenetik
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