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Dokumenttyp:
Journal Article
Autor(en):
Benjamin, EJ; Rice, KM; Arking, DE; Pfeufer, A; van Noord, C; Smith, AV; Schnabel, RB; Bis, JC; Boerwinkle, E; Sinner, MF; Dehghan, A; Lubitz, SA; D'Agostino, RB; Lumley, T; Ehret, GB; Heeringa, J; Aspelund, T; Newton-Cheh, C; Larson, MG; Marciante, KD; Soliman, EZ; Rivadeneira, F; Wang, TJ; Eiriksdottir, G; Levy, D; Psaty, BM; Li, M; Chamberlain, AM; Hofman, A; Vasan, RS; Harris, TB; Rotter, JI; Kao, WH; Agarwal, SK; Stricker, BH; Wang, K; Launer, LJ; Smith, NL; Chakravarti, A; Uitterlinden, AG...     »
Titel:
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
Abstract:
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2009
Band / Volume:
41
Heft / Issue:
8
Seitenangaben Beitrag:
879-81
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.416
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19597492
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Humangenetik
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