Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?-The Munich multicentric enterococci cohort.

Rothe, Kathrin; Bachfischer, Tobias; Karapetyan, Siranush; Hapfelmeier, Alexander; Wurst, Milena; Gleich, Sabine; Dichtl, Karl; Schmid, Roland M; Triebelhorn, Julian; Wagner, Laura; Erber, Johanna; Voit, Florian; Burgkart, Rainer; Obermeier, Andreas; Seibold, Ulrich; Busch, Dirk H; Rämer, Patrick C; Spinner, Christoph D; Schneider, Jochen

doi:10.1128/spectrum.02585-23

Institut für Allgemeinmedizin und Versorgungsforschung (Prof. Schneider)

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Document type:: Journal Article
Author(s):: Rothe, Kathrin; Bachfischer, Tobias; Karapetyan, Siranush; Hapfelmeier, Alexander; Wurst, Milena; Gleich, Sabine; Dichtl, Karl; Schmid, Roland M; Triebelhorn, Julian; Wagner, Laura; Erber, Johanna; Voit, Florian; Burgkart, Rainer; Obermeier, Andreas; Seibold, Ulrich; Busch, Dirk H; Rämer, Patrick C; Spinner, Christoph D; Schneider, Jochen
Title:: Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?-The Munich multicentric enterococci cohort.
Abstract:: The present study provides a substantial contribution to literature, showing that patients with enterococcal bloodstream infections (BSI) have a lower survival rate than those with Escherichia coli (E. coli) bloodstream infections after adjusting for 17 limiting prognostic factors and excluding patients with a limited life expectancy [metastatic tumor disease, Charlson Comorbidity Index (CCI) (greater than or equal to) 5]. This difference in the 5-year long-term survival was mainly driven by Enterococcus faecium (ECFM) bloodstream infections, with vancomycin resistance not being a significant contributing factor. Our findings imply that E. faecium bloodstream infections seem to be an independent risk factor for poor long-term outcomes. As such, future research should confirm this relationship and prioritize investigating its causality through prospective studies. «
The present study provides a substantial contribution to literature, showing that patients with enterococcal bloodstream infections (BSI) have a lower survival rate than those with Escherichia coli (E. coli) bloodstream infections after adjusting for 17 limiting prognostic factors and excluding patients with a limited life expectancy [metastatic tumor disease, Charlson Comorbidity Index (CCI) (greater than or equal to) 5]. This difference in the 5-year long-term survival was mainly driven by Ent... »
Journal title abbreviation:: Microbiol Spectr
Year:: 2023
Journal volume:: 11
Journal issue:: 6
Fulltext / DOI:: doi:10.1128/spectrum.02585-23
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/37791770
Print-ISSN:: 2165-0497
TUM Institution:: Klinik und Poliklinik für Orthopädie und Sportorthopädie (Prof. von Eisenhart-Rothe); Lehrstuhl für Allgemeinmedizin (Prof. Schneider)
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