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Titel:

Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; nicht gelistet
Autor(en):
Ludwig, L; Oswald, F; Hoang-Vu, C; Dralle, H; Hildt, E; Schmid, RM; Karges, W
Abstract:
Inappropriate signaling of the RET receptor tyrosine kinase causes different forms of human thyroid malignancy. We have previously identified the adaptor Grap-2 as RET binding protein. To verify involvement of Grap-2 in RET oncogenic signaling we performed sequence and expression analysis of Grap-2 in 15 human MTC samples. All tumors displayed marked Grap-2 mRNA and protein expression without a linear correlation. Beyond one conservative base pair substitution we detected no further alteration i...     »
Zeitschriftentitel:
Cancer Lett
Jahr:
2009
Band / Volume:
275
Heft / Issue:
2
Seitenangaben Beitrag:
194-7
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.canlet.2008.10.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19027225
Print-ISSN:
0304-3835
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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