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Title:

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Fang, HY; Hughes, R; Murdoch, C; Coffelt, SB; Biswas, SK; Harris, AL; Johnson, RS; Imityaz, HZ; Simon, MC; Fredlund, E; Greten, FR; Rius, J; Lewis, CE
Abstract:
Ischemia exists in many diseased tissues, including arthritic joints, atherosclerotic plaques, and malignant tumors. Macrophages accumulate in these sites and up-regulate hypoxia-inducible transcription factors (HIFs) 1 and 2 in response to the hypoxia present. Here we show that the gene expression profile in primary human and murine macrophages changes markedly when they are exposed to hypoxia for 18 hours. For example, they were seen to up-regulate the cell surface receptors, CXCR4 and GLUT1,...     »
Journal title abbreviation:
Blood
Year:
2009
Journal volume:
114
Journal issue:
4
Pages contribution:
844-59
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2008-12-195941
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19454749
Print-ISSN:
0006-4971
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Roman Herzog Comprehensive Cancer Center
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