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Title:

The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Steinberg, C; Eisenächer, K; Gross, O; Reindl, W; Schmitz, F; Ruland, J; Krug, A
Abstract:
IFN regulatory factor 7 (IRF7) has been described as the master regulator of type I IFN responses and has been shown to be critical for innate antiviral immunity in vivo. In addition to type I IFN, NK cell responses are involved in the control of viral replication during acute viral infection. To investigate the role of IRF7 in the context of a viral infection that induces a strong NK cell response, the murine cytomegalovirus (MCMV) infection model was used. WT, IRF7-deficient and IRF3/IRF7-doub...     »
Journal title abbreviation:
Eur J Immunol
Year:
2009
Journal volume:
39
Journal issue:
4
Pages contribution:
1007-18
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.200838814
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19283778
Print-ISSN:
0014-2980
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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