Effect of short-term high-protein compared with normal-protein diets on renal hemodynamics and associated variables in healthy young men.

Frank, H; Graf, J; Graf, J; Amann-Gassner, U; Bratke, R; Daniel, H; Heemann, U; Hauner, H

doi:10.3945/ajcn.2009.27601

journal article

Title:: Effect of short-term high-protein compared with normal-protein diets on renal hemodynamics and associated variables in healthy young men.
Document type:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):: Frank, H; Graf, J; Graf, J; Amann-Gassner, U; Bratke, R; Daniel, H; Heemann, U; Hauner, H
Abstract:: BACKGROUND: High-protein diets are effective for weight reduction; however, little is known about the potential adverse renal effects of such diets. OBJECTIVE: The aim of our study was to compare the effect of a high-protein (HP) with a normal-protein (NP) diet on renal hemodynamics and selected clinical-chemical factors. DESIGN: We prospectively studied the effect of an HP diet (2.4 g x kg(-1) x d(-1)) with that of an NP diet (1.2 g x kg(-1) x d(-1)) on the glomerular filtration rate (assessed on the basis of sinistrin-an inulin analog-clearance) and renal plasma flow (para-aminohippuric acid clearance) by using the constant infusion technique. Filtration fraction and renal vascular resistance were calculated. Twenty-four healthy young men followed the 2 diet protocols for 7 d each in a crossover design. They were individually advised by a dietitian to achieve the planned protein intake by selecting normal foods under isocaloric conditions. Serum and urinary variables and renal hemodynamics were measured on day 7 of both diets. RESULTS: The glomerular filtration rate (NP: 125 +/- 5 mL/min; HP: 141 +/- 8 mL/min; P < 0.001) and filtration fraction (NP: 23 +/- 5%; HP: 28 +/- 5%; P < 0.05) increased significantly with the HP diet. Renal plasma flow was not significantly different between the HP (496 +/- 25 mL/min) and NP (507 +/- 18 mL/min) phases. Renal vascular resistance was not significantly different between the NP (94 +/- 6 mm Hg x mL(-1) x min(-1)) and HP (99 +/- 8 mm Hg x mL(-1) x min(-1)) phases. Blood urea nitrogen, serum uric acid, glucagon, natriuresis, urinary albumin, and urea excretion increased significantly with the HP diet. CONCLUSIONS: A short-term HP diet alters renal hemodynamics and renal excretion of uric acid, sodium, and albumin. More attention should be paid to the potential adverse renal effects of HP diets.
Journal title abbreviation:: Am J Clin Nutr
Year:: 2009
Journal volume:: 90
Journal issue:: 6
Pages contribution:: 1509-16
Language:: eng
Fulltext / DOI:: doi:10.3945/ajcn.2009.27601
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/19812175
Print-ISSN:: 0002-9165
TUM Institution:: Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; Fachgebiet Nephrologie (Prof. Heemann)
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