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Titel:

Ribozyme to TGF-beta1 mRNA abrogates immunosuppressive effects of human colorectal adenocarcinoma HRT-18 cells in vitro and in vivo.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schmitt, WD; Siegert, A; Lach, SS; Fuhrmann, S; Kondla, A; Holm, PS; Hauptmann, S
Abstract:
Transforming growth factor-beta1 (TGF-beta1) is overexpressed in a variety of malignant epithelial tumors and was suggested to be a marker of colorectal cancer. Moreover, there is growing evidence that TGF-beta1 contributes to tumor progression by regulating tumor cell proliferation and differentiation, inducing a favorable tumor microenvironment, promoting migration and invasion, and suppressing macrophage cytotoxicity. Therefore, we stably transfected an anti-TGF-beta1 hammerhead ribozyme into...     »
Zeitschriftentitel:
Int J Oncol
Jahr:
2009
Band / Volume:
35
Heft / Issue:
4
Seitenangaben Beitrag:
901-8
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19724928
Print-ISSN:
1019-6439
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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