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Titel:

Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.

Dokumenttyp:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Autor(en):
Thiermann, H; Worek, F; Eyer, P; Eyer, F; Felgenhauer, N; Zilker, T
Abstract:
OBJECTIVE: The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. In this article we report effects on neuromuscular function, oxime and atropine concentration, and relate them to acetylcholinesterase (AChE) activity. METHODS: We measured the activity of cholinesterase in plasma and AChE in red blood cells (RBC) and related these data with neuromuscular transmission analysis (ulnar nerve stimulation). Concomitantly, p...     »
Zeitschriftentitel:
Clin Toxicol (Phila)
Jahr:
2009
Band / Volume:
47
Heft / Issue:
8
Seitenangaben Beitrag:
807-13
Sprache:
eng
Volltext / DOI:
doi:10.1080/15563650903206836
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19778190
Print-ISSN:
1556-3650
TUM Einrichtung:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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