[Lead intoxication in a group of workers in Germany]

Willi, RF; Felgenhauer, N; Eyer, F; Buters, JT; Zilker, T

doi:10.1055/s-0029-1243060

2009

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Title:: [Lead intoxication in a group of workers in Germany]
Document type:: English Abstract; Journal Article; Article
Author(s):: Willi, RF; Felgenhauer, N; Eyer, F; Buters, JT; Zilker, T
Abstract:: HISTORY AND ADMISSION FINDINGS: Seventeen East-European workers with a suspected lead-intoxication presented themselves to the Department of Toxicology. All of them had worked on the renovation of pylons of a high-tension line. The old paint, known to contain lead was removed with needle descalers. The patients had blood lead concentrations between 325 and 1124 microg/l, but no specific symptoms. The workers neglected the protective measures at their working-place. INVESTIGATIONS: 12 of 17 workers had lead-concentrations above 400 microg/l (Reference < 90 microg/l). 10 of 17 patients showed an increased level of free protoporphyrins and all workers showed a decreased activity of delta-aminolaevulinacid-dehydratase (ALAD). TREATMENT AND COURSE: Patients with lead-concentration above 700 microg/l were treated with the chelating agent meso-2,3-dimercaptosuccinic acid (DMSA) 3 x 200 mg/d for nine days. The patients with lead concentrations between 400 and 700 microg/l were treated which DMSA 3 x 100 mg/d. After the DMSA-treatment the lead-concentrations had dropped (p < 0.001). During the DMSA-therapy one patient had to be treated in the hospital because of a generalised allergic exanthema. CONCLUSION: We report seventeen patients with high lead concentration in their blood due to occupational exposure. The high blood lead levels showed that the workers had not been protected adequately. This examplifies that occupational lead exposure still occurs, also in Germany. By patients with unspecific symptoms connected with lead exposure a biomonitoring for lead is necessary.
Journal title abbreviation:: Dtsch Med Wochenschr
Year:: 2009
Journal volume:: 134
Journal issue:: 50
Pages contribution:: 2556-60
Language:: de
Fulltext / DOI:: doi:10.1055/s-0029-1243060
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/19998225
Print-ISSN:: 0012-0472
TUM Institution:: 2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker); Molekulare Allergologie (Prof. Schmidt-Weber)
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