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Title:

Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.

Document type:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Author(s):
Thiermann, H; Worek, F; Eyer, P; Eyer, F; Felgenhauer, N; Zilker, T
Abstract:
OBJECTIVE: The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. In this article we report effects on neuromuscular function, oxime and atropine concentration, and relate them to acetylcholinesterase (AChE) activity. METHODS: We measured the activity of cholinesterase in plasma and AChE in red blood cells (RBC) and related these data with neuromuscular transmission analysis (ulnar nerve stimulation). Concomitantly, p...     »
Journal title abbreviation:
Clin Toxicol (Phila)
Year:
2009
Journal volume:
47
Journal issue:
8
Pages contribution:
807-13
Language:
eng
Fulltext / DOI:
doi:10.1080/15563650903206836
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19778190
Print-ISSN:
1556-3650
TUM Institution:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker)
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