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Titel:

Y-box-binding protein YB-1 identifies high-risk patients with primary breast cancer benefiting from rapidly cycled tandem high-dose adjuvant chemotherapy.

Dokumenttyp:
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Autor(en):
Gluz, O; Mengele, K; Schmitt, M; Kates, R; Diallo-Danebrock, R; Neff, F; Royer, HD; Eckstein, N; Mohrmann, S; Ting, E; Kiechle, M; Poremba, C; Nitz, U; Harbeck, N
Abstract:
PURPOSE: To investigate the potential of Y-box-binding protein YB-1, a multifunctional protein linked to tumor aggressiveness and multidrug resistance, to identify patients with breast cancer likely to benefit from dose-intensified chemotherapy regimens. PATIENTS AND METHODS: YB-1 was immunohistochemically determined in 211 primary tumors from the prospective, randomized West German Study Group WSG-AM-01 trial in high-risk (> or = 10 involved lymph-nodes) breast cancer (HRBC). Predictive impact...     »
Zeitschriftentitel:
J Clin Oncol
Jahr:
2009
Band / Volume:
27
Heft / Issue:
36
Seitenangaben Beitrag:
6144-51
Sprache:
eng
Volltext / DOI:
doi:10.1200/JCO.2008.19.6261
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19901122
Print-ISSN:
0732-183X
TUM Einrichtung:
Frauenklinik und Poliklinik
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