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Titel:

Identification of Novel Susceptibility Genes for Breast Cancer - Genome-Wide Association Studies or Evaluation of Candidate Genes?

Dokumenttyp:
Review
Autor(en):
Meindl, A
Abstract:
To determine the genetic components that constitute polygenic traits in familial or sporadic breast cancer, low-risk variants on the one hand and mutations conferring moderate penetrance on the other hand have to be identified. While members of the latter group were found by comprehensive screening of candidate genes which are, like the 2 highly penetrant genes BRCA1/BRCA2, located in the DNA repair pathway, the development of novel techniques was urgently needed to identify low-risk variants. T...     »
Zeitschriftentitel:
Breast Care (Basel)
Jahr:
2009
Band / Volume:
4
Heft / Issue:
2
Seitenangaben Beitrag:
93-99
Sprache:
eng
Print-ISSN:
1661-3791
TUM Einrichtung:
Frauenklinik und Poliklinik
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