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Titel:

Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker.

Dokumenttyp:
Journal Article; Article
Autor(en):
Sadr-Nabavi, A; Ramser, J; Volkmann, J; Naehrig, J; Wiesmann, F; Betz, B; Hellebrand, H; Engert, S; Seitz, S; Kreutzfeld, R; Sasaki, T; Arnold, N; Schmutzler, R; Kiechle, M; Niederacher, D; Harbeck, N; Dahl, E; Meindl, A
Abstract:
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) was recently described as an antagonist of angiogenesis. Motivated by a strong dependence of tumor growth and metastasis on angiogenesis, we investigated the role of EFEMP1 in human breast cancer. We applied RNA microarray expression analysis and quantitative real-time PCR (QRT) in a total of 45 sporadic breast cancer tissues and found EFEMP1 down-regulation in 59% and 61% of the analyzed tissues, respectively. This down-regulat...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2009
Band / Volume:
124
Heft / Issue:
7
Seitenangaben Beitrag:
1727-35
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.24108
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19115204
Print-ISSN:
0020-7136
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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