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Titel:

The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil.

Dokumenttyp:
Journal Article; Article
Autor(en):
Ben Fredj, R; Gross, E; Ben Ahmed, S; Hassine, H; Saguem, S
Abstract:
A rapid and cost-effective reversed phase high performance liquid chromatography (HPLC) method for quantification of dihydrouracil to uracil ratio (UH2/U) in plasma has been developed and used to screen for dihydropyrimidine dehydrogenase (DPD) deficiency in nine patients treated with 5-fluorouracil (5-FU). This HPLC method is based on the use of a simultaneous UV detection at 205 and 268nm during the analysis run of the plasma extract and taking into account the particularity that UH2 shows no...     »
Zeitschriftentitel:
Pathol Biol (Paris)
Jahr:
2009
Band / Volume:
57
Heft / Issue:
6
Seitenangaben Beitrag:
470-6
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.patbio.2008.05.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18619742
Print-ISSN:
0369-8114
TUM Einrichtung:
Frauenklinik und Poliklinik
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