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- Titel:
Magnetic resonance imaging of the ankle at 3.0 Tesla and 1.5 Tesla in human cadaver specimens with artificially created lesions of cartilage and ligaments.
- Dokumenttyp:
- journal article
- Autor(en):
- Bauer, JS; Barr, C; Henning, TD; Malfair, D; Ma, CB; Steinbach, L; Link, TM
- Abstract:
- PURPOSE: To compare magnetic resonance imaging of the ankle joint at 1.5 Tesla (T) and 3.0 T in the assessment of cartilage and ligament pathology in fresh human cadaver specimens. MATERIALS AND METHODS: The study was performed in line with institutional and legislative requirements; all donors had dedicated their body for educational and research purposes before death. Thirteen fresh human cadaver ankle joints were imaged at 1.5 T and 3.0 T using an optimized clinical ankle protocol consisting of T1-weighted (T1-w), fat-saturated (fs) T2-w, and short tau inversion recovery fast spinecho (FSE) sequences. For dedicated cartilage imaging, fs-intermediate (IM)-w FSE, fs-spoiled gradient echo, and balanced free precession steady state sequences were acquired. Artificial cartilage and ligament lesions were created in 6 and 5 specimens, respectively. MR imaging was repeated in those ankles. Four radiologists independently assessed pathology in all image datasets. Macroscopic findings after dissection served as a reference standard. RESULTS: Sensitivities and ROC-values were higher at 3.0 T for detecting cartilage pathology (sensitivity up to 0.71 at 3.0 T vs. 0.49 at 1.5 T; AZ up to 0.88 vs. 0.74; both differences P< 0.05) and highest for the fs-IM FSE sequence at 3.0 T. Average sensitivity for detecting ligament pathology was higher at 3.0 T (0.69 vs. 0.50; P< 0.05). Specificity was high among all protocols and both field strengths for assessing ligament and cartilage pathology (>0.95). CONCLUSION: Compared with 1.5-T imaging, the 3.0-T imaging of the ankle joint at improved diagnostic performance in assessing cartilage significantly and there was a higher sensitivity for assessing ligamentous pathology.
- Zeitschriftentitel:
- Invest Radiol
- Jahr:
- 2008
- Band / Volume:
- 43
- Heft / Issue:
- 9
- Seitenangaben Beitrag:
- 604-11
- Sprache:
- eng
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/18708853
- Print-ISSN:
- 0020-9996
- TUM Einrichtung:
- Institut für Radiologie
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