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Title:

Administration of interleukin-1 receptor antagonist ameliorates renal ischemia-reperfusion injury.

Document type:
Journal Article
Author(s):
Rusai, K; Huang, H; Sayed, N; Strobl, M; Roos, M; Schmaderer, C; Heemann, U; Lutz, J
Abstract:
Interleukin (IL)-1 is a major contributor to inflammation and apoptosis during ischemia/reperfusion (I/R) injury. Its deleterious effects are primarily mediated by the activation of nuclear factor-kappaB (NF-kappaB). Receptor-binding and signaling of IL-1 can be blocked by the IL-1 receptor antagonist (IL-1ra). The aim of our study was to characterize effects and mechanisms of IL-1ra administration on inflammation, apoptosis, and infiltration in renal I/R injury. Renal ischemia was induced in Le...     »
Journal title abbreviation:
Transpl Int
Year:
2008
Journal volume:
21
Journal issue:
6
Pages contribution:
572-80
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1432-2277.2008.00651.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18363573
Print-ISSN:
0934-0874
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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