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Title:

Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Article
Author(s):
Lin, D; Kamsteeg, EJ; Zhang, Y; Jin, Y; Sterling, H; Yue, P; Roos, M; Duffield, A; Spencer, J; Caplan, M; Wang, WH
Abstract:
In the present study, we tested the role of CD63 in regulating ROMK1 channels by protein-tyrosine kinase (PTK). Immunocytochemical staining shows that CD63 and receptor-linked tyrosine phosphatase alpha (RPTPalpha) are expressed in the cortical collecting duct and outer medulla collecting duct. Immunoprecipitation of tissue lysates from renal cortex and outer medulla or 293T cells transfected with CD63 reveals that CD63 was associated with RPTPalpha both in situ and in transfected cells. Express...     »
Journal title abbreviation:
J Biol Chem
Year:
2008
Journal volume:
283
Journal issue:
12
Pages contribution:
7674-81
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M705574200
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18211905
Print-ISSN:
0021-9258
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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