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Document type:
journal article
Author(s):
Schaefer, M; Reiling, N; Fessler, C; Stephani, J; Taniuchi, I; Hatam, F; Yildirim, AO; Fehrenbach, H; Walter, K; Ruland, J; Wagner, H; Ehlers, S; Sparwasser, T
Title:
Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection.
Abstract:
Dendritic cell (DC)-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN: CD209) is a C-type lectin that binds ICAM-2,3 and various pathogens such as HIV, helicobacter, and mycobacteria. It has been suggested that Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, interacts with DC-SIGN to evade the immune system. To directly analyze the role of human DC-SIGN during mycobacterial infection, we generated conventional transgenic (tg) mice (termed "hSIGN"...    »
Journal title abbreviation:
J Immunol
Year:
2008
Journal volume:
180
Journal issue:
10
Pages contribution:
6836-45
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18453604
Print-ISSN:
0022-1767
TUM Institution:
III. Medizinische Klinik und Poliklinik
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