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Title:

VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Beckermann, BM; Kallifatidis, G; Groth, A; Frommhold, D; Apel, A; Mattern, J; Salnikov, AV; Moldenhauer, G; Wagner, W; Diehlmann, A; Saffrich, R; Schubert, M; Ho, AD; Giese, N; Büchler, MW; Friess, H; Büchler, P; Herr, I
Abstract:
Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth factors present in pancreatic tumours, such as PDGF, EGF, VEGF and specific inhibitors Glivec, Erbitux and Avastin interfered with migration. Within a few hours, MSC migrated into spheroids consisting of pancreatic cancer cells, fibroblasts and endothe...     »
Journal title abbreviation:
Br J Cancer
Year:
2008
Journal volume:
99
Journal issue:
4
Pages contribution:
622-31
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.bjc.6604508
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18665180
Print-ISSN:
0007-0920
TUM Institution:
Chirurgische Klinik und Poliklinik
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