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Title:

The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma.

Document type:
Journal Article; Article
Author(s):
Erkan, M; Michalski, CW; Rieder, S; Reiser-Erkan, C; Abiatari, I; Kolb, A; Giese, NA; Esposito, I; Friess, H; Kleeff, J
Abstract:
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with an innate resistance to therapy. Pancreatic stellate cells (PSCs) produce this excessively desmoplastic microenvironment. The impact of PSC activity on PDAC behavior in vivo is analyzed. METHODS: 233 patients who underwent surgery for PDAC were evaluated by immunohistochemistry using antibodies against alpha-smooth muscle actin as a marker of PSC activity. Aniline was used to stain collagen depositio...     »
Journal title abbreviation:
Clin Gastroenterol Hepatol
Year:
2008
Journal volume:
6
Journal issue:
10
Pages contribution:
1155-61
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cgh.2008.05.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18639493
Print-ISSN:
1542-3565
TUM Institution:
Chirurgische Klinik und Poliklinik
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