Benutzer: Gast  Login
Titel:

The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma.

Dokumenttyp:
Journal Article; Article
Autor(en):
Erkan, M; Michalski, CW; Rieder, S; Reiser-Erkan, C; Abiatari, I; Kolb, A; Giese, NA; Esposito, I; Friess, H; Kleeff, J
Abstract:
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with an innate resistance to therapy. Pancreatic stellate cells (PSCs) produce this excessively desmoplastic microenvironment. The impact of PSC activity on PDAC behavior in vivo is analyzed. METHODS: 233 patients who underwent surgery for PDAC were evaluated by immunohistochemistry using antibodies against alpha-smooth muscle actin as a marker of PSC activity. Aniline was used to stain collagen depositio...     »
Zeitschriftentitel:
Clin Gastroenterol Hepatol
Jahr:
2008
Band / Volume:
6
Heft / Issue:
10
Seitenangaben Beitrag:
1155-61
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cgh.2008.05.006
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18639493
Print-ISSN:
1542-3565
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
 BibTeX