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Title:

Distinct Functionality of Tumor Cell-Derived Gelatinases during Formation of Liver Metastases.

Document type:
Journal Article; Article
Author(s):
Gerg, M; Kopitz, C; Schaten, S; Tschukes, A; Kahlert, C; Stangl, M; Hann von Weyhern, CW; Brücher, BL; Edwards, DR; Brand, K; Kruger, A
Abstract:
The specific spatiotemporal role of the matrix metalloproteinase 2 (MMP-2) and MMP-9 (gelatinase) during metastasis is still under debate. Host cells have been described as major contributors to these MMPs during metastasis. Here, we show strong overexpression of MMP-2 and MMP-9 by tumor cells of clinical liver specimen of recurrent metachronous metastases, leading us to address the importance of tumor cell-derived MMP-2 or MMP-9 during liver metastasis. Thus far, distinction of their roles was...     »
Journal title abbreviation:
Mol Cancer Res
Year:
2008
Journal volume:
6
Journal issue:
3
Pages contribution:
341-51
Language:
eng
Fulltext / DOI:
doi:10.1158/1541-7786.MCR-07-2032
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18337444
Print-ISSN:
1541-7786
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
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