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Title:

Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2.

Document type:
Journal Article
Author(s):
Qiao, L; Dai, Y; Gu, Q; Chan, KW; Ma, J; Lan, HY; Zou, B; Röcken, C; Ebert, MP; Wong, BC
Abstract:
We investigated whether the anticancer effect of a combination of XIAP down-regulation and PPAR gamma activation on colon cancer is PPARgamma receptor dependent. HCT116-XIAP(+/+) cells and HCT116-XIAP(-/-) cells were treated with troglitazone or 15-deoxy-Delta(12,14)-prostaglandin J2 (15-PGJ2) with or without prior exposure to PPARgamma inhibitor GW9662. Cell proliferation and apoptosis was evaluated. Athymic mice carrying HCT116-XIAP(-/-) cells-derived tumors were treated with troglitazone in t...     »
Journal title abbreviation:
Cancer Lett
Year:
2008
Journal volume:
268
Journal issue:
2
Pages contribution:
260-71
Language:
eng
Fulltext / DOI:
doi:10.1016/j.canlet.2008.04.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18477501
Print-ISSN:
0304-3835
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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