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- Titel:
The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study.
- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Frank, B; Rigas, SH; Bermejo, JL; Wiestler, M; Wagner, K; Hemminki, K; Reed, MW; Sutter, C; Wappenschmidt, B; Balasubramanian, SP; Meindl, A; Kiechle, M; Bugert, P; Schmutzler, RK; Bartram, CR; Justenhoven, C; Ko, YD; Bruning, T; Brauch, H; Hamann, U; Pharoah, PP; Dunning, AM; Pooley, KA; Easton, DF; Cox, A; Burwinkel, B
- Abstract:
- A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95... »
- Zeitschriftentitel:
- Breast Cancer Res Treat
- Jahr:
- 2008
- Band / Volume:
- 111
- Heft / Issue:
- 1
- Seitenangaben Beitrag:
- 139-44
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1007/s10549-007-9752-z
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/17891485
- Print-ISSN:
- 0167-6806
- TUM Einrichtung:
- Frauenklinik und Poliklinik
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