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Title:

Patterns of alphavbeta3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Beer, AJ; Niemeyer, M; Carlsen, J; Sarbia, M; Nährig, J; Watzlowik, P; Wester, HJ; Harbeck, N; Schwaiger, M
Abstract:
The integrin alpha(v)beta(3) is a key player in angiogenesis and metastasis. Our aim was to study the uptake patterns of the alpha(v)beta(3)-selective PET tracer (18)F-galacto-RGD in invasive ductal breast cancer. METHODS: Sixteen patients with primary (n = 12) or metastasized breast cancer (n = 4) were examined with (18)F-galacto-RGD PET. Standardized uptake values (SUVs) were derived by region-of-interest analysis, and immunohistochemistry of alpha(v)beta(3) expression was performed (n = 5). R...     »
Journal title abbreviation:
J Nucl Med
Year:
2008
Journal volume:
49
Journal issue:
2
Pages contribution:
255-9
Language:
eng
Fulltext / DOI:
doi:10.2967/jnumed.107.045526
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18199623
Print-ISSN:
0161-5505
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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