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Titel:

Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.

Dokumenttyp:
Journal Article; Article
Autor(en):
Yfanti, C; Mengele, K; Gkazepis, A; Weirich, G; Giersig, C; Kuo, WL; Tang, WJ; Rosner, M; Schmitt, M
Abstract:
Insulin-degrading enzyme (IDE, insulysin, insulinase; EC 3.4.22.11), a thiol metalloendopeptidase, is involved in intracellular degradation of insulin, thereby inhibiting its translocation and accumulation to the nucleus. Recently, protein expression of IDE has been demonstrated in the epithelial ducts of normal breast and breast cancer tissue. Utilizing four different antibodies generated against different epitopes of the IDE molecule, we performed Western blot analysis and immunohistochemical...     »
Zeitschriftentitel:
Int J Mol Med
Jahr:
2008
Band / Volume:
22
Heft / Issue:
4
Seitenangaben Beitrag:
421-31
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18813847
Print-ISSN:
1107-3756
TUM Einrichtung:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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