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Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Berg, T; Fliegauf, M; Bürger, J; Staege, MS; Liu, S; Martinez, N; Heidenreich, O; Burdach, S; Haferlach, T; Werner, MH; Lübbert, M
Title:
Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.
Abstract:
An inducible model for conditional expression of AML1-ETO in myeloid U-937 cells was generated previously to determine cellular effects of AML1-ETO and to identify target genes. Induction of AML1-ETO expression in U-937 resulted in reduced cell growth, G1 arrest and apoptosis. Microarray analysis showed more genes up-regulated than down-regulated (180 vs. 69). Clustering of AML1-ETO-positive and -negative cell lines was possible based on these differentially expressed genes. p21/WAF/Cip1 (CDKN1A...     »
Journal title abbreviation:
Haematologica
Year:
2008
Journal volume:
93
Journal issue:
11
Pages contribution:
1728-33
Language:
eng
Fulltext / DOI:
doi:10.3324/haematol.13044
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18790797
Print-ISSN:
0390-6078
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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