Magnetic resonance imaging of the ankle at 3.0 Tesla and 1.5 Tesla in human cadaver specimens with artificially created lesions of cartilage and ligaments.

Bauer, JS; Barr, C; Henning, TD; Malfair, D; Ma, CB; Steinbach, L; Link, TM

journal article

Title:: Magnetic resonance imaging of the ankle at 3.0 Tesla and 1.5 Tesla in human cadaver specimens with artificially created lesions of cartilage and ligaments.
Document type:: journal article
Author(s):: Bauer, JS; Barr, C; Henning, TD; Malfair, D; Ma, CB; Steinbach, L; Link, TM
Abstract:: PURPOSE: To compare magnetic resonance imaging of the ankle joint at 1.5 Tesla (T) and 3.0 T in the assessment of cartilage and ligament pathology in fresh human cadaver specimens. MATERIALS AND METHODS: The study was performed in line with institutional and legislative requirements; all donors had dedicated their body for educational and research purposes before death. Thirteen fresh human cadaver ankle joints were imaged at 1.5 T and 3.0 T using an optimized clinical ankle protocol consisting of T1-weighted (T1-w), fat-saturated (fs) T2-w, and short tau inversion recovery fast spinecho (FSE) sequences. For dedicated cartilage imaging, fs-intermediate (IM)-w FSE, fs-spoiled gradient echo, and balanced free precession steady state sequences were acquired. Artificial cartilage and ligament lesions were created in 6 and 5 specimens, respectively. MR imaging was repeated in those ankles. Four radiologists independently assessed pathology in all image datasets. Macroscopic findings after dissection served as a reference standard. RESULTS: Sensitivities and ROC-values were higher at 3.0 T for detecting cartilage pathology (sensitivity up to 0.71 at 3.0 T vs. 0.49 at 1.5 T; AZ up to 0.88 vs. 0.74; both differences P< 0.05) and highest for the fs-IM FSE sequence at 3.0 T. Average sensitivity for detecting ligament pathology was higher at 3.0 T (0.69 vs. 0.50; P< 0.05). Specificity was high among all protocols and both field strengths for assessing ligament and cartilage pathology (>0.95). CONCLUSION: Compared with 1.5-T imaging, the 3.0-T imaging of the ankle joint at improved diagnostic performance in assessing cartilage significantly and there was a higher sensitivity for assessing ligamentous pathology.
Journal title abbreviation:: Invest Radiol
Year:: 2008
Journal volume:: 43
Journal issue:: 9
Pages contribution:: 604-11
Language:: eng
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/18708853
Print-ISSN:: 0020-9996
TUM Institution:: Institut für Radiologie
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mediaTUM Gesamtbestand Hochschulbibliographie 2008 Fakultäten Medizin Institut für Radiologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Institut für Radiologie und Nuklearmedizin 2008