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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Hoffmann, S; Cepok, S; Grummel, V; Lehmann-Horn, K; Hackermueller, J; Stadler, PF; Hartung, HP; Berthele, A; Deisenhammer, F; Wasmuth, R; Hemmer, B
Title:
HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis.
Abstract:
The formation of antibodies to interferon-beta (IFN-beta), a protein-based disease-modifying agent for multiple sclerosis (MS), is a problem in clinical practice. These antibodies may neutralize the biological effects of the protein drug, potentially decreasing its therapeutic effects. By high-resolution HLA class I and II typing we identified two HLA class II alleles associated with the development of antibodies to IFN-beta. In two independent continuous and binary-trait association studies, HL...    »
Journal title abbreviation:
Am J Hum Genet
Year:
2008
Journal volume:
83
Journal issue:
2
Pages contribution:
219-27
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ajhg.2008.07.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18656179
Print-ISSN:
0002-9297
TUM Institution:
Neurologische Klinik und Poliklinik
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